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Contraindicated (1)pentobarbital will lessen the level or outcome of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females must not select estradiol valerate/dienogest as their contraceptive when working with potent CYP3A4 inducers on account of potential reduce in contraceptive efficacy.p